Publications

I seem to have been only like a boy playing on the seashore, and diverting myself in now and then finding a smoother pebble or a prettier shell than ordinary, whilst the great ocean of truth lay all undiscovered before me.

Isaac Newton

all
selected
2022
2021
2020
2019
2018-2013
Selected
  • Wang, Minxian, Ramesh Menon, Sanghamitra Mishra, Aniruddh P. Patel, et al. “Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians.” Journal of the American College of Cardiology 76.6 (2020), pp. 703–714. doi: 10.1016/j.jacc.2020.06.024.
  • Aniruddh P. Patel*, Wang, Minxian* Yunfeng Ruan, Pradeep Natarajan, and Amit V. Khera#. “A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease.” Nature Medicine (2023), e1–15. 76.6 (2020), pp. 703–714. doi: 10.1038/s41591-023-02429-x
  • Sumeet A. Khetarpal*, Wang, Minxian*, and Amit V. Khera. “Volanesorsen, familial chylomicronemia syndrome, and thrombocytopenia.” New England Journal of Medicine 381.26 (2019), pp. 2582–2584. doi: 10.1056/NEJMc1912350.
  • Saaket Agrawal*, Wang, Minxian*, Marcus D.R. Klarqvist, Kirk Smith, et al. “Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots.” Nature Communications 13.1 (2022), p. 2021.08.24.21262564. DOI: 10.1038/s41467-022-30931-2.
  • Akl C Fahed*, Wang, Minxian*, Julian R Homburger*, Aniruddh P Patel, et al. “Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions.” Nature communications 11.1 (2020), p. 3635. doi: 10.1038/s41467-020-17374-3.
  • Wang, Minxian, Justin Chun, Giulio Genovese, Andrea U Knob, et al. “Contributions of rare gene vari- ants to familial and sporadic FSGS.” Journal of the American Society of Nephrology 30.9 (2019), pp. 1625– 1640. doi: 10.1681/ASN.2019020152.
  • Jia-Yue Zhang*, Wang, Minxian*#, Lei Tian, Giulio Genovese, et al. “UBD modifies APOL1 -induced kidney disease risk.” Proceedings of the National Academy of Sciences (2018), p. 201716113. doi: 10.1073/ pnas.1716113115.
  • Wang, Minxian, Xin Huang, Ran Li, Hongyang Xu, Li Jin, and Yungang He. “Detecting Recent Positive Selection with High Accuracy and Reliability by Conditional Coalescent Tree.” Molecular biology and evolution 31.11 (Aug. 2014), pp. 3068–3080. doi: 10.1093/molbev/msu244.
2022
  • Saaket Agrawal*, Wang, Minxian*, Marcus D.R. Klarqvist, Kirk Smith, et al. “Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots.” Nature Communications 13.1 (2022), p. 2021.08.24.21262564. DOI: 10.1038/s41467-022-30931-2.
  • Amit V Khera*, Wang, Minxian*, Mark Chaffin Ms, Connor A Emdin, et al. “Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease.” Circulation. Genomic and precision medicine003598.December (2022), pp. 1–9. DOI: 10.1161/CIRCGEN.121.003598.
  • Aniruddh P Patel, Jacqueline S Dron, Wang , Minxian, James P Pirruccello, et al. “Association of Pathogenic DNA Variants Predisposing to Cardiomyopathy With Cardiovascular Disease Outcomes and All-Cause Mortality.” JAMA Cardiol 7.7 (July 2022), pp. 723–732.
  • Julian Milosavljevic, Lempicki, [...], Wang, Minxian, et al. “Nephrotic syndrome gene TBC1D8B is required for endosomal maturation and nephrin endocytosis in Drosophila.” J. Am. Soc. Nephrol. (Sept. 2022), ASN.2022030275.
  • Lihong Peng, Jialiang Yang, Wang, Minxian, and Liqian Zhou. “Editorial: Machine learning-based methods for RNA data analysis.” Front. Genet. 13 (May 2022), p. 828575.
  • Akl C. Fahed, Wang, Minxian, Aniruddh P. Patel, Ezimamaka Ajufo, et al. “Association of the Interaction Between Familial Hypercholesterolemia Variants and Adherence to a Healthy LifestyleWith Risk of Coronary Artery Disease.” JAMA Network Open 5.3 (2022), e222687. DOI: 10.1001/jamanetworkopen.2022.2687.
  • Kiran J Biddinger, Connor A Emdin, Mary E Haas, Wang, Minxian, George Hindy, Patrick T Ellinor, and Sekar Kathiresan. “Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease.” JAMA Network Open 5.3 (2022), pp. 1–12. DOI: 10.1001/jamanetworkopen.2022.3849.
  • Justin Chun, Cristian Riella, [...], Wang, Minxian, et al. “DGAT2 Inhibition Potentiates Lipid Droplet Formation to Reduce Cytotoxicity in APOL1 Kidney Risk Variants.” Journal of the American Society of Nephrology (Mar. 2022). DOI: 10.1681/ASN.2021050723.
2021
  • Wang, Minxian, Vivian S. Lee-Kim, Deepak S. Atri, Nadine H. Elowe, et al. “Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large- Scale Sequencing Analyses.” Circulation: Genomic and Precision Medicine(Oct. 2021). DOI: 10.1161/CIRCGEN.121.003399.
  • George Hindy, Peter Dornbos, [...], Wang, Minxian, et al. “Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes.” The American Journal of Human Genetics(2021), pp. 1–16. DOI: 10.1016/j.ajhg.2021.11.021.
  • Mary E. Haas, James P. Pirruccello, Samuel N. Friedman, Wang, Minxian, et al. “Machine learning enables new insights into genetic contributions to liver fat accumulation.” Cell Genomics 1.3 (2021), p. 100066. DOI: 10.1016/j.xgen.2021.100066.
  • Veryan Codd, Qingning Wang, [...], Wang,Minxian, et al. “Polygenic basis and biomedical consequences of telomere length variation.” Nature Genetics 2021 53:10 53.10 (Oct. 2021), pp. 1425–1433. DOI: 10.1038/s41588-021-00944-6.
  • Aniruddh P. Patel, Wang, Minxian, Uri Kartoun, Kenney Ng, and Amit V. Khera. “Quantifying and Understanding the Higher Risk of Atherosclerotic Cardiovascular Disease Among South Asian Individuals.” Circulation(Aug. 2021), pp. 410–422. DOI: 10.1161/CIRCULATIONAHA.120.052430.
  • María José Pérez-Sáez, Audrey Uffing, [...], Wang, Minxian, et al. “Immunological Impact of a Gluten-Free Dairy-Free Diet in Children With Kidney Disease: A Feasibility Study.” Frontiers in Immunology 12.June (2021), pp. 1–11. DOI: 10.3389/fimmu.2021.624821
  • Yudong Cai, Jialiang Yang, Tao Huang, and Wang, Minxian. “Editorial: Computational Methods in Predicting Complex Disease Associated Genes and Environmental Factors.” Frontiers in Genetics (2021). doi: 10.3389/fgene.2021.679651.
  • Jacqueline S Dron*, Wang, Minxian*, Aniruddh P Patel, Uri Kartoun, Kenney Ng, Robert A Hegele, and Amit V Khera. “Genetic Predictor to Identify Individuals With High Lipoprotein(a) Concentrations.” Circulation: Genomic and Precision Medicine (Feb. 2021), CIRCGEN120003182. doi: 10.1161/CIRCGEN.120. 003182.
  • Patricia L Weng, Amar J Majmundar, [...], Wang, Minxian, et al. “De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis.” American journal of human genetics 108.2 (Feb. 2021), pp. 357–367. doi: 10.1016/j. ajhg.2021.01.008.
2020
  • Wang, Minxian, Ramesh Menon, Sanghamitra Mishra, Aniruddh P. Patel, et al. “Validation of a Genome- Wide Polygenic Score for Coronary Artery Disease in South Asians.” Journal of the American College of Cardiology 76.6 (2020), pp. 703–714. doi: 10.1016/j.jacc.2020.06.024.
  • Akl C Fahed*, Wang, Minxian*, Julian R Homburger*, Aniruddh P Patel, et al. “Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions.” Nature communications 11.1 (2020), p. 3635. doi: 10.1038/s41467-020-17374-3.
  • Aniruddh P. Patel*,Wang, Minxian*, Akl C. Fahed, Heather Mason-Suares, et al. “Association of Rare Pathogenic DNA Variants for Familial Hypercholesterolemia, Hereditary Breast and Ovarian Cancer Syn- drome, and Lynch Syndrome With Disease Risk in Adults According to Family History.” JAMA network open 3.4 (2020), e203959. doi: 10.1001/jamanetworkopen.2020.3959.
  • Connor A. Emdin*, Pallav Bhatnagar*, Wang, Minxian*, Sreekumar G. Pillai, et al. “Genome-wide poly- genic score and cardiovascular outcomes with evacetrapib in patients with high-risk vascular disease: A nested case-control study.” Circulation: Genomic and Precision Medicine February (2020), pp. 30–32. doi: 10.1161/CIRCGEN.119.002767.
  • Justin Chun*, Wang, Minxian*, Maris S. Wilkins, Andrea U. Knob, Ava Benjamin, Lihong Bu, and Martin R. Pollak. “Autosomal Dominant Tubulointerstitial Kidney Disease—Uromodulin Misclassified as Focal Segmental Glomerulosclerosis or Hereditary Glomerular Disease.” Kidney International Reports 5.4 (2020), pp. 519–529. doi: 10.1016/j.ekir.2019.12.016.
  • Aniruddh P. Patel, Wang, Minxian, James P. Pirruccello, Patrick T. Ellinor, Kenney Ng, Sekar Kathire- san, and Amit V. Khera. “Lp(a) (Lipoprotein[a]) Concentrations and Incident Atherosclerotic Cardiovas- cular Disease.” Arteriosclerosis, Thrombosis, and Vascular Biology December (2020), pp. 1–10. doi: 10.1161/ atvbaha.120.315291.
  • James P Pirruccello, Alexander Bick, Wang, Minxian, Mark Chaffin, et al. “Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy.” Nature communications 11.1 (2020), p. 2254. doi: 10.1038/s41467-020-15823-7.
  • Di Feng, Mukesh Kumar, [...], Wang, Minxian, et al. “Phosphorylation of ACTN4 leads to podocyte vulnerability and proteinuric glomerulosclerosis.” Journal of the American Society of Nephrology 31.7 (2020), pp. 1479–1495. doi: 10.1681/ASN.2019101032.
2019
  • Sumeet A. Khetarpal*, Wang, Minxian*, and Amit V. Khera. “Volanesorsen, familial chylomicronemia syndrome, and thrombocytopenia.” New England Journal of Medicine 381.26 (2019), pp. 2582–2584. doi: 10.1056/NEJMc1912350.
  • Wang, Minxian, Justin Chun, Giulio Genovese, Andrea U Knob, et al. “Contributions of rare gene vari- ants to familial and sporadic FSGS.” Journal of the American Society of Nephrology 30.9 (2019), pp. 1625– 1640. doi: 10.1681/ASN.2019020152.
  • Amit V. Khera, Heather Mason-Suares, Deanna Brockman, Wang, Minxian, et al. “Rare Genetic Vari- ants Associated With Sudden Cardiac Death in Adults.” Journal of the American College of Cardiology 74.21 (2019), pp. 2623–2634. doi: 10.1016/j.jacc.2019.08.1060.
  • Cristian Riella, Tobias A. Siemens, Wang, Minxian, Rodrigo P. Campos, et al. “APOL1-Associated Kidney Disease in Brazil.” Kidney International Reports 4.7 (2019), pp. 923–929. doi: 10.1016/j.ekir.2019.03. 006.
2018-2013
  • Jia-Yue Zhang*, Wang, Minxian*#, Lei Tian, Giulio Genovese, et al. “UBD modifies APOL1 -induced kidney disease risk.” Proceedings of the National Academy of Sciences (2018), p. 201716113. doi: 10.1073/ pnas.1716113115.
  • Di Feng, Jacob Notbohm, Ava Benjamin, Shijie He, Wang, Minxian, Lay-hong Ang, and Minaspi Bantawa. “Disease-causing mutation in α -actinin-4 promotes podocyte detachment through maladaptation to periodic stretch.” Proceedings of the National Academy of Sciences 115.7 (2018), pp. 1517–1522. doi: 10.1073/pnas.1717870115.
  • Yungang He, Wang, Minxian, Xin Huang, Ran Li, Hongyang Xu, Shuhua Xu, and Li Jin. “A probabilistic method for testing and estimating selection differences between populations.” Genome Research 25.12 (Dec. 2015), pp. 1903–1909. doi: 10.1101/gr.192336.115.
  • Bin Zhou, Hui Dong, [...], Wang, Minxian, et al. “Composition and Interactions of Hepatitis B Virus Quasispecies Defined the Virological Response during Telbivudine Therapy.” Scientific Reports 5.July (2015), pp. 1–10. doi: 10.1038/srep17123.
  • Wang, Minxian, Xin Huang, Ran Li, Hongyang Xu, Li Jin, and Yungang He. “Detecting Recent Positive Selection with High Accuracy and Reliability by Conditional Coalescent Tree.” Molecular biology and evolution 31.11 (Aug. 2014), pp. 3068–3080. doi: 10.1093/molbev/msu244.
  • Yueming Jiang*, Wang, Minxian*, Hongxiang Zheng, Wei R Wang, Li Jin, and Yungang He. “Resolving ambiguity in the phylogenetic relationship of genotypes A, B, and C of hepatitis B virus.” BMC evolutionary biology 13.1 (Jan. 2013), p. 120. doi: 10.1186/1471-2148-13-120.
  • Ran Li, Wang, Minxian, Li Jin, and Yungang He. “A Monte Carlo permutation test for random mating using genome sequences.” PloS one 8.8 (Jan. 2013), e71496. doi: 10.1371/journal.pone.0071496.